Flutamide in men with prostatic intraepithelial neoplasia: a randomized, placebo-controlled chemoprevention trial

SR Alberts, PJ Novotny, JA Sloan… - American journal of …, 2006 - journals.lww.com
… We therefore conducted a chemoprevention trial assessing the efficacy of flutamide in … This
study showed no evidence of benefit from flutamide as a chemoprevention agent in men with …

[HTML][HTML] Chemoprevention of prostate cancer in men with high-grade prostatic intraepithelial neoplasia (HGPIN): a systematic review and adjusted indirect treatment …

K Cui, X Li, Y Du, X Tang, S Arai, Y Geng, Y Xi, H Xu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Direct meta-analysis were performed to summarize the efficacy of candidate
chemopreventative agents Dutasteride, Flutamide, Toremifene, Selenium, Green tea components, …

A randomized phase IIb presurgical study of finasteride vs. low-dose flutamide vs. placebo in men with prostate cancer. Efficacy monitored by karyometry

R Montironi, PH Bartels, A DeCensi, M Puntoni… - … Oncology: Seminars and …, 2013 - Elsevier
… , phase IIB, placebo controlled, double-blind, presurgical study … to the high-grade prostatic
intraepithelial neoplasia in the … : A randomized, placebo-controlled chemoprevention trial

Flutamide reduced prostate cancer development and prostate stem cell antigen mRNA expression in high grade prostatic intraepithelial neoplasia

Z Zhigang, S Wenlu - International journal of cancer, 2008 - Wiley Online Library
… a randomized, placebo-controlled, double-blind study of … Using this 250 mg/day as a
chemopreventive dose for human … In this study, only 3 (3%) of 86 men treated with flutamide were …

Androgen antagonists: potential role in prostate cancer prevention

DL Trump, JA Waldstreicher, G Kolvenbag, PS Wissel… - Urology, 2001 - Elsevier
… as a potential chemopreventive agent for prostate cancer. Anti-… placebo-controlled trial
in 3,000 men. At baseline, the mean … (eg, prostatic intraepithelial neoplasia, abnormal PSA, …

Phase IIA clinical trial to test the efficacy and safety of Toremifene in men with high-grade prostatic intraepithelial neoplasia

MS Steiner, CR Pound - Clinical prostate cancer, 2003 - Elsevier
… -finding, randomized, placebo-controlled phase IIB/III study is … for chemoprevention; had
evidence of prostate cancer on … There is also evidence that cessation of flutamide resulted in …

[HTML][HTML] High-grade prostatic intraepithelial neoplasia

DG Bostwick, J Qian - Modern pathology, 2004 - Elsevier
… Inhibition of angiogenesis may be an effective method of chemoprevention, particularly for
men at high … Similarly, a prospective, placebo-controlled study of TRAMP mice treated with an …

Prostate cancer chemoprevention agent development: the National Cancer Institute, Division of Cancer Prevention portfolio

HL Parnes, MG House, J Kagan, DJ Kausal… - The Journal of …, 2004 - Elsevier
… , phase 2 trial of flutamide and is currently sponsoring a phase 3, placebo controlled trial of
… We have a prostatic intraepithelial neoplasia (PIN) trial open in Canada from which we are …

Premalignancy in prostate cancer: rethinking what we know

AM De Marzo, MC Haffner, TL Lotan… - Cancer prevention …, 2016 - AACR
… High-grade prostatic intraepithelial neoplasia (PIN) has been … of chemoprevention trials
employed enrichment of men with … Randomized, placebo-controlled, end-of-study prostate

Abstract PR-03: Randomized presurgical trial of finasteride vs. flutamide vs. placebo in prostate cancer

S Zanardi, M Maffezzini, M Puntoni, R Montironi… - Cancer Prevention …, 2010 - AACR
… : Prostate cancer (PC) is an ideal target for chemoprevention, with high-grade prostatic
intraepithelial neoplasia (… randomized phase IIB placebo-controlled double-blind presurgical …